Exploring Key Biomarkers and Common Pathogenesis of Seven Digestive System Cancers and Their Correlation with COVID-19

Digestive system cancer and COVID-19 significantly affect the digestive system, but mechanism of interaction between cancers has not been fully elucidated. We downloaded gene expression seven (oral, esophageal, gastric, colorectal, hepatocellular, bile duct, pancreatic) from GEO identified hub differentially expressed genes. Multiple verifications, diagnostic efficacy, prognostic analysis, functional enrichment related transcription factors genes were explored. 23 common DEGs for subsequent analysis. CytoHubba nine (CCNA2, CCNB1, CDKN3, ECT2, KIF14, KIF20A, KIF4A, NEK2, TTK). TCGA data validated excellent ability Functional analysis revealed that processes cell division cycle essential in cancers. Furthermore, six (E2F1, E2F3, E2F4, MYC, TP53, YBX1) involved regulation. Via vitro experiments, CCNA2, MYC was verified 25 colorectal tissue pairs. Our study key biomarks pathogenesis COVID-19. These may provide new ideas further mechanistic research.